Helping prometheus: liver protection in acute hemorrhagic shock
نویسندگان
چکیده
منابع مشابه
Vasodilator Therapy in Acute Hemorrhagic Shock.
• Irreversible shock associated with acute blood loss is a serious clinical problem.' Attempts have been made to treat this form of shock with a variety of therapeutic agents including vasopressor drugs, steroids, and plasma expanders. Most popular has been the employment of the vasopressor agents, levarterenol (Levophed) and metaraminol (Aramine), which support blood pressure mainly through an...
متن کاملReduction of hemorrhagic shock–induced acute kidney injury by lower limb ischemic preconditioning in rats
Introduction: During hemorrhagic shock (HS), the kidneys are one of the primary target organs involved. Oxidative stress is shown to be enhanced in different models of acute kidney injury (AKI). Remote ischemic preconditioning (RPC) by brief limb ischemia is considered to be a safe method to protect different organs from further damage. In this study, we investigated the effects of brief hind l...
متن کاملMaraviroc-Mediated Lung Protection following Trauma-Hemorrhagic Shock
Objectives. The peroxisome proliferator-activated receptor gamma (PPARγ) pathway exerts anti-inflammatory effects in response to injury. Maraviroc has been shown to have potent anti-inflammatory effects. The aim of this study was to investigate whether PPARγ plays an important role in maraviroc-mediated lung protection following trauma-hemorrhage. Methods. Male Sprague-Dawley rats underwent tra...
متن کاملUlinastatin mediates protection against vascular hyperpermeability following hemorrhagic shock.
OBJECT Recent studies have suggested that intrinsic apoptotic signaling cascade is involved in endothelial barrier dysfunction following hemorrhagic shock (HS), which results in vascular hyperpermeability. Our previous study demonstrated that ulinastatin (UTI) inhibits oxidant-induced endothelial hyperpermeability and apoptotic signaling. In present study, we hypothesized that UTI would improve...
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ژورنال
عنوان ژورنال: Annals of Translational Medicine
سال: 2017
ISSN: 2305-5839,2305-5847
DOI: 10.21037/atm.2017.03.109